Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a disintegrant in pharmaceutical formulations. The cross-linking reduces water solubility while still allowing the material to swell and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas' subsequent bioavailability. Croscarmellose sodium also resolves formulators' concerns over long-term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products developed to enhance drug dissolution. Croscarmellose sodium is a pure, white, with fibrous particles, free-flowing powder which does not interfere with binding or flow at typical use levels. In tablets, concentrations as low as 1% may be used. Generally, a 2% level is recommended for tablets made by direct compression, and a 3% level is typical for those products made by wet granulation.

Features and product benefits Good water uptake (high capillary action) Rapid swelling properties Relatively long fiber length provides     efficient fluid channeling Excellent long-term dissolution stability Dissolution/disintegration independent of     tablet hardness Highly effective in direct compression     and wet granulation Low use level. Typical use levels of     0.5%-3%

Applications Superior dissolution aid and disintegrant     for pharmaceutical formulations * Tablet * Capsule * Caplet

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